By combining structural insights with our antibody drug discovery platform and deep understanding of the underlying biology, our scientific outlook is all-encompassing. We consider ideas, findings, and beliefs about validated targets (past and present) and extend them with our critical science to realize great pharmacological potential.
Structural Insights & the Growth Factor Precursor
Unlike traditional approaches, we target growth factors in their inactive precursor, or latent, forms to selectively regulate their activity in the microenvironment of cells and tissues. We applied this extraordinary selectivity across a number of growth factors, including to transforming growth factor beta (TGFβ), and are on the path to achieving novel discoveries.
Our proprietary platform aids in our development of antibody drugs that apply to targets living in the scientific crossroads of biologically understood and structurally misunderstood.
Recent PublicationsView More Publications
April 17, 2020
Journal of Biological Chemistry
Structural basis of specific inhibition of extracellular activation of pro- or latent myostatin by the monoclonal antibody SRK-015
March 25, 2020
Science Translational Medicine
Selective inhibition of TGFB1 activation overcomes primary resistance to checkpoint blockade therapy by altering tumor immune landscape
July 26, 2019
A Sensitive and Selective Immunoassay for the Quantitation of Serum Latent Myostatin after In Vivo Administration of SRK-015, a Selective Inhibitor of Myostatin Activation
Recent PostersView More Posters
Society for Immunotherapy of Cancer's (SITC) Annual Meeting
DRAGON: Phase 1 trial of SRK-181, a latent TGFβ1 inhibitor, in combination with anti-PD-(L)1 inhibitors for patients with solid tumors unresponsive to anti-PD-(L)1 therapy alone
World Muscle Society
Clinical Development of SRK-015,a Fully Human Anti-proMyostatin Monoclonal Antibody, for the Treatment of Later-Onset Spinal Muscular Atrophy
World Muscle Society
Myostatin Dynamics in Health and Disease: Pharmacologic Effects of SRK-015, a Highly Selective Monoclonal Antibody Inhibitor of Myostatin Activation