Publications

Long, K., O’Shea, K., Khairallah, R., et al. Specific Inhibition of Myostatin Activation is Beneficial in Mouse Models of SMA Therapy. 2018. Human Molecular Genetics, ddy382

Pirruccello-Straub M, Jackson J, Wawersik S, Webster MT, Salta L, Long K, McConaughy W, Capili A, Boston C, Carven GJ, Mahanthappa NK, Turner KJ, Donovan A. Blocking extracellular activation of myostatin as a strategy for treating muscle wasting. 2018. Sci Rep 8:20524-9

Le VQ, Iacob RE, Tian Y, McConaughy W, Jackson J, Su Y, Zhao B, Engen JR, Pirruccello-Straub M, Springer TA. Tolloid cleavage activates latent GDF8 by priming the pro-complex for dissociation. 2017. EMBO J 37(3): 384-97

Posters

The Society for Immunotherapy of Cancer (SITC) 33rd Annual Meeting — November 2018
Defeating checkpoint resistance: Highly specific inhibition of latent TGFβ1 activation renders resistant solid tumors vulnerable to PD-1 blockade

12th International BMP Conference — October 2018
RGMc-selective antibodies modulate iron homeostasis in vivo

Gordon Research Conference — March 2018
Discovery of an isoform-specific inhibitor of TGFb1 activation using antibody display technology

European SMA Research Congress — January 2018
Inhibition of myostatin activation by SRK-015 promotes muscle strength in a multiple mouse models of SMA

ASN Kidney Week — November 2017
A novel, highly specific TGFβ1 inhibiting antibody demonstrates antifibrotic activity without cardiotoxicity

CURE SMA Annual Conference — June 2017
Scholar Rock’s Novel Approach to Improving Muscle Function in SMA Patients

Federation of American Societies for Experimental Biology — April 2017
Highly specific inhibition of TGFβ1 activation with antibody SR-AB1 has antifibrotic activity

Gordon Research Conference— August 2017
Identification of LTBP Complex-Specific Inhibitors of Latent TGFβ1 Activation

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