Neuromuscular and Obesity

Targeting Myostatin

Myostatin is a member of the TGFβ superfamily of protein growth factors and is mainly expressed in skeletal muscle cells. Myostatin works with other growth factors and hormones to regulate muscle mass by limiting growth.

Scholar Rock has pioneered a unique anti-myostatin therapeutic approach that targets the latent, or inactive, form of myostatin with exquisite selectivity to inhibit, or prevent, its activation. Traditional treatment approaches target active myostatin that is harder to selectively target.

We are developing investigational anti-myostatin therapies for spinal muscular atrophy (SMA) and cardiometabolic disorders, including obesity.