BMP6 Signaling

Iron is essential for many metabolic processes, and is critically important in the development and function of red blood cells. It serves as a carrier of oxygen to the tissues from the lungs by hemoglobin in red blood cells, as a transport medium for electrons within cells, and as a cofactor of important enzymes in various tissues. A number of disease states as well as rare genetic mutations can cause disruptions in iron homeostasis and can result in either iron deficiency or overload. These imbalances in iron levels can lead to serious and debilitating conditions for which there are few effective and safe therapies. The therapies that do exist are only effective for a limited number of patients.

Our preclinical programs in hematology are focused on modulating the supracellular activation of BMP6, a key regulator of the biological system that regulates systemic iron levels to treat diseases associated with dysregulation of iron metabolism while minimizing the side effects of available therapies.

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